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All models were docked into the EM density map using Chimera 52 , followed by iterative manual adjustment and real-space refinement using COOT 53 and fragment-based refinement with Rosetta 54
The analysis also includes tirzepatide (Mounjaro and Zepbound), which is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 agonist (and classified under A10BX or other blood glucose lowering drugs, excl
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Buchwald and Oien, 2009
