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By the 1970s, one hormone was identified as an incretin candidate: Gastric Inhibitory Polypeptide (GIP) , discovered in 196970, which was found to stimulate insulin secretion (and renamed Glucose-Dependent Insulinotropic Polypeptide ) ( [30] )

Although the primary endpoint 12-month smoking abstinence did not reach statistical significance, secondary outcomes were encouraging: dulaglutide was associated with reduced nicotine cravings, less post-cessation weight gain, and higher self-reported satisfaction with the quitting process []

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