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Weekly subcutaneous tirzepatide yields substantial weight loss in patients with or without diabetes

While tirzepatide may produce faster initial effects, both medications reach therapeutic effectiveness with consistent use and proper dose escalation

When tirzepatide activates GLP-1 receptors, it enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying

Mounjaro is primarily eliminated through kidneys, and has a half-life of 5 days

Not to be outdone, Eli Lilly, the manufacturer of the type 2 diabetes medication Mounjaro (which mimics both GLP-1 as well the GI hormone gastric inhibitory peptide (GIP)), is in the final stretch of FDA-approval of its active ingredient, tirzepatide, as a weight management medication as well