glp 1 agonist news Researchers find GLP-1 medications safe to continue before surgery in patients with diabetes and obesity GLP-1 receptor agonists confer 'modest'
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What Does This Mean for Patients
3,5 In early T2DM managed with lifestyle alone, orforglipron lowered glycated hemoglobin A1c (HbA1c) by -1.24 to -1.48 percentage points over 40 weeks as compared to -0.41 with placebo, with no severe hypoglycemia reported and weight reduction ranging from 4.5% to 7.6%, 3 which led to mean HbA1c levels of 6.5-6.7%
Bethel MA, Patel RA, Thompson VP, et al
However, adverse gastrointestinal effects generally preclude the use of higher doses, even with adjusted uptitration dosing algorithms [734,877]
doi: 10.1053/j.gastro.2015.04.014 quiz e15-6
