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Safety Considerations and Side Effects of GLP-1 Agonists Whilst GLP-1 receptor agonists are generally well-tolerated, patients and prescribers must be aware of potential adverse effects and important safety considerations

Chapter 19: Adverse effects

Safety Concerns and Risks Despite their efficacy, GLP-1 RAs present several safety concerns that must be carefully evaluated in adolescent populations

GLP-1 receptor agonists are now widely prescribed for individuals with type 2 diabetes and weight loss, with a 700% increase in usage reported in the United States between 2019 and 2023. These medications alter glucose metabolism, gastric motility, and sympathetic tone, which may lead to unique uptake patterns on PET-CT