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Nevertheless, pharmacodynamic studies of antidiabetic drugs have been conducted irregularly in these patients.31,32 In addition, only few studies3337 (Table 2) have evaluated the rate of control of hyperglycemia,33,34 the effectiveness of specific drugs,35 the impact of treatment on morbidity and mortality36,37 and the safety of antidiabetic drugs.3337 In one of such studies, effective glycemic control was achieved in only a small proportion of patients with HCV/HBV infection (34.2 and 23.5% respectively).34 In another study, treatment was effective in only 28% of patients largely due to the toxicity of the drugs