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Description
The Lancet Diabetes & Endocrinology , 10(1), 45-57
By pre-treating rats with the non-specific cholinergic receptor antagonist atropine as well as the specific M3 cholinergic receptor antagonist 4-DAMP and performing vagotomy, the researchers found that atropine and 4-DAMP significantly reduced metformin-induced GLP-1 secretion, whereas vagotomy had no effect on metformin-induced GLP-1 secretion
~12.4% in non-diabetics
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And that's exactly why India's drug regulators have stepped in
