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Appetite suppression can sometimes mask disordered eating
A) Activation of POMC neurons by GLP-1 and 5-HT, particularly through the 5-HT2C receptor, leads to the release of -MSH, an endogenous agonist for MC4R
GLP-1 receptor agonists (e.g., semaglutide, dulaglutide, liraglutide) work by mimicking natural GLP-1 hormone to stimulate insulin secretion, suppress glucagon, slow gastric emptying, and promote satiety
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doi: 10.1038/sj.npp.1301234 165 RaoM.GershonM
