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Policymakers, insurers, and employers must weigh the benefits of expanding access to these effective medications against the potentiallyunsustainable coststhey introduce.

Participants received diet (500kcaldeficit per day) and exercise counseling during 2-week run-in, before being randomly assigned (with a telephone or web-based system) to once-daily subcutaneous liraglutide (1.2, 1.8, 2.4 or 3.0mg, n=9095), placebo (n=98) or open-label orlistat (120mg 3, n=95)

However, some types of eating disorders could worsen with GLP1-RA and require monitoring and treatment by registered dietitian and/or behavioral health providers who specialize in eating disorders, with appropriate referrals to higher levels of care for disordered eating.

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Focus on the Right Fats Not all fats influence GLP-1 equally