triple glp-1/gip/glucagon receptor agonist retatrutide mechanism glp-1 gip glucagon Treatment with retatrutide, an agonist to GLP-1 The Road towards Triple Agonists:

424 In AD, GLP-1(7-36) amide inhibits IL-1 transcription and prevents cognitive dysfunction, amyloid precursor protein synthesis, and cell death

Lilly's ASC30 confusingly named, no relation to Ascletis ASC35 sorry, different molecule entirely Lilly's portfolio includes investigational quarterly injectables

Cell Metab 2006;3:15365

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

1 If the decision is made for the patient to remain on a GLP1RA, they should be switched to a GLP1RA that is not contraindicated at lower eGFR levels (dulaglutide, liraglutide or OW semaglutide)