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For diabetes management, the standard dose is 1.8 mg injected daily, while for weight loss, the dose is increased to 3 mg daily.10 Titration begins at 0.6 mg/day, increasing weekly by 0.6 mg until the 3 mg maintenance dose is reached, typically over a five-week period.10 Clinical guidelines recommend liraglutide for long-term use when combined with lifestyle modifications

It is recommended to inject Wegovy, or Zepbound once weekly on the same day each week

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The synergy also explains why dose titration matters so much more with retatrutide than with simpler compounds

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