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Waqas SA, Sohail MU, Saad M et al (2025) Efficacy of GLP-1 Receptor Agonists in Patients with Heart Failure and Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis
LA supervised the study and is the guarantor
The covariates included age (modelled as a continuous variable using cubic splines with five knots at the 5th, 27.5th, 50th, 72.5th, and 95th centiles), sex, smoking status, body mass index, alcohol related disorders, and cohort entry year (2013-15, 2016-18, 2019-21)
If metabolic health matters more than the scale Dulaglutide offers the strongest cardiovascular outcome data among GLP-1 agonists
Most "plateaus" on tirzepatide are actually expected metabolic slowdowns at lower body weights, not medication failure
