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You should contact your GP if you experience: Persistent diarrhoea lasting more than seven days, or sooner if you have blood in your stool, fever, signs of dehydration, or severe abdominal pain Pale, clay-coloured stools , which may indicate reduced bile flow and potential biliary obstruction Dark urine combined with pale stools and jaundiceseek same-day or urgent assessment, as this may indicate significant liver dysfunction or bile duct problems Steatorrhoea (fatty, greasy stools that float and are difficult to flush), which may indicate fat malabsorption Unexplained weight loss alongside bowel changes Persistent change to looser or more frequent stools , particularly if you are aged 60 or overyour GP may arrange tests including a faecal immunochemical test (FIT) and, where appropriate, consider an urgent referral to rule out bowel cancer (in line with NICE guideline NG12) Seek urgent help via NHS 111 or 999 if you have: Severe abdominal pain with fever, confusion, or rigors (shaking chills), which may indicate a serious infection Jaundice with dark urine, pale stools, and feeling systemically unwell If you have been diagnosed with fatty liver disease, regular monitoring is essential even in the absence of symptoms

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Reduction of Hyperinsulinaemia and IGF-1 Signalling Elevated circulating insulin and insulin-like growth factor-1 (IGF-1) represent well-established promoters of tumour cell proliferation

New Concern: Counterfeit Retatrutide Products Health officials have recently issued warnings about products being sold as retatrutide, an experimental weight loss medication that has not been approved by the FDA or other major regulatory agencies

Metabolism 2013