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These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]

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These findings suggest that GLP-1RAs may offer a promising option for T2D patients concerned about cancer risk, especially those who are drug-naive

semaglutide for diabetes in 2017, for obesity in 2021)