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Persistent diarrhea on GLP-1 can come from bile acid malabsorption, which causes watery, urgent stools often in the morning or soon after eating

NCBI Bookshelf [2] Kommu, S., & Whitfield, P

For patients with well-controlled Graves disease who are euthyroid on antithyroid medications or following definitive treatment (radioactive iodine or thyroidectomy), tirzepatide may be considered if there are appropriate indications such as type 2 diabetes or obesity (BMI 30 kg/m or 27 kg/m with weight-related comorbidities)

Agonism of these receptors range from a gastroprokinetic to increase gut motility (5-HT type 4) to anxiolytic and anti-depressant (5-HT type 6) and a potential analgesic (5-HT type 7)

This raises theoretical concerns about oral contraceptive absorption