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in ob/ob mice (163)

Meanwhile, individuals who took a high-potency GLP-1 drug approved for obesity - such as semaglutide - had greater persistence at 14% three years after initiating therapy

Another study showed that acute administration of exenatide was associated with increased hepatic glucose uptake during an oral glucose tolerance test (OGTT) and a reduction in endogenous glucose production, reinforcing the hypothesis of a direct action of GLP-1 on the liver [12]

Combination therapy of GLP-1 analogues with swallowable balloon for treatment of obesity

GIP (or glucose-dependent insulinotropic polypeptide) is another hormone in some of these medications