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Interestingly, it has been shown that rats consuming a 3 g meal displayed significant elevations in plasma GLP-1 within 56 min only in the hepatoportal vein and not in the vena cava [78], suggesting that, under physiological conditions, GLP-1R within the CNS is only reached by brain-derived GLP-1, since GLP-1 is also expressed by a discrete population of caudal brainstem neurons localized to neurons within the caudal (visceral) nucleus of the solitary tract (cNST) and adjacent medullary reticular formation in rodents and primates, including humans [83,84,85,86]

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PLoS ONE 10:e0132744 [DOI] [PMC free article] [PubMed] [Google Scholar] 56.Pal S, Maurya SK, Chattopadhyay S, Pal China S, Porwal K, Kulkarni C, Sanyal S, Sinha RA, Chattopadhyay N (2019) The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts

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This shift can impact the amount of food purchased, the types of foods purchased, and the amount of food wasted. Participants were then asked to rate the likelihood that GLP-1 drugs will impact economic outcomes (e.g., profitability) of different food system players, from 1=very unlikely to 7=very likely

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Renal, metabolic and cardiovascular considerations of SGLT2 inhibition

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