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In vitro, GLP-1 enhanced brain-derived neurotrophic factor (BDNF) secretion and ameliorated mitochondrial dysfunction and cell toxicity via cAMP/PKA activation in A-treated astrocytes [50]

Earlier in the year, Novos semaglutide-based GLP-1 drugs (including Ozempic and Wegovy) were listed among the drugs subject to Medicare pricing negotiations, with the negotiated price dropping 71% for Medicare beneficiaries, set to take effect in 2027

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How These Drugs May Reduce Addiction Scientists believe the effect is linked to how these medications influence the brain

7,8 Our preliminary data have shown that GLP-1 receptor agonism reduces CSF secretion and intracranial pressure (ICP) in an in vivo rodent model with elevated ICP