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55 In a broad sense, these findings suggest that effects of GIP on cardiac remodeling may differ based on the ambient pathophysiologic milieu

Theyre smaller in molecular weight than peptide medications that mimic or interfere with endogenous bioregulatory peptides. Think of it this way: While a peptide is like a fragile piece of paper that dissolves in the rain, a small molecule is like a tiny pebble, sturdy enough to survive the digestive storm

Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations

9 At system level, oral GLP-1s also align with scalable healthcare delivery models

They didnt discover something brand new, Dr
