how well does oral semaglutide work vs Injectable Semaglutide: Which Is More Effective? The Semaglutide Pill vs. Injection:

That, in turn, may lead to real healthcare troubles

Currently, two ongoing clinical trials are investigating the role of GLP-1 RAs in IBD management, that would lead to further knowledge: a French study (ID NCT05196958) evaluating the safety and efficacy of GLP-1 RAs in treatment of DM2 in overweight IBD patients (115), and an American study (ID NCT06774079) comparing the efficacy of GLP-1 RAs tirzepatide versus diet in CD patients (116)

(2024) Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor

Jastreboff, A.M., Aronne, L.J., Ahmad, N.N., et al

Some studies indicate that high sodium intake may affect insulin signalling pathways and contribute to oxidative stress, potentially exacerbating metabolic dysfunction