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Accessed 2024 Jan 25

After a meal, active GLP1 is released from the gut into the bloodstream, which then promotes insulin secretion and suppresses glucagon secretion, leading to a reduction in glucose levels

To lose weight faster on semaglutide, you should eat healthy, drink plenty of water, stay active and limit your alcohol intake

Similarly, in the SURMOUNT-1 trial of tirzepatide, lean mass was reduced by 5.67 kg or 10.9% from baseline, with a weight reduction of 22.1 kg or 20.9% (with the highest dose), yielding a fraction of weight lost from lean mass of 25.7% [175]

What This Means for GLP-1 Users A probiotic might modestly support gut transit, based on the meta-analysis evidence, but the magnitude is modest, the strain-level evidence is heterogeneous, and there is no direct trial in GLP-1 users