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Suitable candidates include: Patients with type 2 diabetes and a BMI of 35 kg/m or higher (or 32.5 kg/m or higher for people of South Asian or other minority ethnic backgrounds), or where weight loss would benefit other significant obesity-related comorbidities Those with type 2 diabetes who have not achieved target HbA1c levels with metformin and other oral medications People for whom weight loss would benefit other obesity-related comorbidities or where weight-neutral treatment options are preferred Individuals with occupational implications where insulin therapy would be problematic Importantly, NICE recommends continuing GLP-1 receptor agonist treatment only if there is a beneficial metabolic response: after 6 months, treatment should continue only if HbA1c has decreased by at least 11 mmol/mol (1.0%) and weight has decreased by at least 3% from initial body weight

I feel like I can cut out a lot of things and the scale hardly moves, its really frustrating, Ann Brown said

The comparison between semaglutide, tirzepatide, and retatrutide reveals the rapidly advancing science of GLP-1 based treatments

Conversely, genetic profiles showing strong GLP-1R activation typically allow more flexibility with portion sizes because the medication creates deeper fullness signals

Tirzepatide activates both GIP and GLP-1 receptors, which may alter tolerability and gastrointestinal effects compared to semaglutide's single GLP-1 mechanism