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Bottom line: While you cannot cure medication-induced allodynia directly, most patients find relief through a combination of wearing loose clothing, staying hydrated, and working with their provider to manage their dosage

This is called adaptive thermogenesis or metabolic adaptation. Key findings: Studies document an average reduction of 100-120 kcal/day in resting metabolic rate beyond whats predicted by body composition changes This adaptation can begin within just ONE WEEK of caloric restriction and persists throughout weight loss Your body decreases both resting energy expenditure (REE) and non-resting energy expenditure to slow weight loss Research shows this can reduce energy expenditure by 5-15% beyond whats expected The mechanisms: Decreased T3 thyroid hormone (see mechanism #3) Reduced sympathetic nervous system activity Lower leptin levels signaling energy scarcity Decreased brown adipose tissue (BAT) activity the tissue responsible for heat generation Reduced NEAT (Non-Exercise Activity Thermogenesis)you unconsciously move less Why you feel cold: Less metabolic activity = less heat production

The decision about whether any compounded GLP-1 medication is appropriate for your specific situation rests with your evaluating clinician

The Cochrane collaborations tool for assessing risk of bias in randomized trials

The drug received FDA approval for the treatment of obstructive sleep apnea in 2024