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Thirdly, residual confounding is a possibility owing to the observational nature of the study

However, there are other data that would challenge the simple explanation that the reduction in feeding and body weight resulting from CNS GLP1R agonism is simply explained by inducing an aversive visceral state

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Additionally, in the analyses of WL after surgery and before treatment, the intercepts were also positive for age with p-value = 0.07 and p-value = 0.09 for GLP-1RAs and placebo treatment groups, respectively, suggesting that older age may be associated with slightly reduced WL

Rezaie, G.A