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GLP-1R is a B-class GPCR that acts on both Gq and Gs signaling, comparable to the other incretin hormone glucose-dependent insulinotropic polypeptides (GIPs), though they only activate the Gs signaling pathway

These associations remained consistent across subgroup analyses, including patients using tirzepatide as adjunctive therapy to other first-line diabetes agents, among patients older than 60 and comparisons against individual GLP-1 drugs, including semaglutide and dulaglutide