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A high expression levels of influx transporters in cells might allow a much higher accumulation of metformin resulting in selective toxicity and cell death as has been postulated to explain the anti-cancer effects of the drug (158)
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There is evidence that the use of dipeptidyl peptidase-4 inhibitors (DPP-4) (gliptins) and/or glucagon-like peptide-1 (GLP-1) mimetics is associated with a higher rate of Parkinson's disease compared with the use of other oral antidiabetic drugs 2
However, reported side effects are consistent with its incretin-based mechanism of action
