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Endogenous hyperinsulinemia may cause weight gain and obesity [30], and treatment with insulin causes substantial weight gain, and may even increase cardiovascular risk [31]

Tirzepatide reduces birth control pill effectiveness by about 60% [8]
10.1007/s40618-021-01687-1 [DOI] [PubMed] [Google Scholar] 28.Malavazos AE, Iacobellis G, Dozio E, Basilico S, Di Vincenzo A, Dubini C, et al

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Although infrequent, severe complications such as pancreatitis and gallbladder disease along with thyroid C-cell hyperplasia have been observed, and rodent research indicates a potential risk for developing medullary thyroid carcinoma [10]
