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The short half-life of native GLP- 1-based therapy in the circulation (approximately two minutes after intravenous administration and one to five hours after subcutaneous administration) posed a problem during its early development [9]

Older adults may have thinner skin that is more prone to bruising
In a recent study, tirzepatide achieved greater reductions in HbA1c levels compared to other commonly used diabetes medications

The MHRA (Medicines and Healthcare products Regulatory Agency) authorized Mounjaro for use in adults age 18 and over in November 2023 and the drug was launched to market in February 2024