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GLP-1 receptor agonists are medications that imitate the effects of glucagon-like peptide-1, a hormone released after eating

A meta-analysis of clinical trials suggested that the highest dose of tirzepatide (15 mg) was associated with the highest risk for nausea, vomiting, and diarrhea when compared to a placebo and other doses

Other research shows the mechanism may be more closely related to berberines antioxidant activity

These drugs are used to treat illnesses such as type 2 diabetes and obesity

While this might seem like a positive outcome, it actually reflects the body's attempt to conserve water in response to reduced intake.The researchers concluded that " GLP-1 receptor agonists reduce fluid intake and thirst perception in patients with primary polydipsia and could therefore be a treatment option for these patients"