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9 Distinguishing failed biology from failed pharmacology: a decision framework A central objective of this review is to distinguish peptidereceptor systems that were abandoned due to intrinsic biological limitations from those that failed primarily because of incomplete pharmacologic execution

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The core principles are simple: Protein at every meal (1.2-1.6g/kg daily) Hydration (2-3L water daily) Small, frequent meals (work with slow stomach emptying, not against it) Avoid fried, greasy, and ultra-sweet foods Fiber increase gradually Follow these principles, and youll not only lose weight youll feel better, preserve muscle, and build habits that last long after you reach your goal weight

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