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Diabetes Obes Metab 27:583594 Leiter LA, Yoon K-H, Arias P et al (2015) Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: a randomized, double-blind, phase 3 study

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do not leave at ambient temperature for extended periods Do not freeze the reconstituted solution freezing can cause peptide aggregation and irreversible loss of biological activity Protect from light by storing the vial in its original packaging, as ultraviolet exposure can accelerate oxidative degradation Minimise repeated punctures of the vial septum to reduce the risk of microbial contamination Label the vial clearly with the date and time of reconstitution, and the pharmacy-assigned beyond-use date, to track the usable window accurately Temperature excursions even brief periods outside the 28 C range can meaningfully reduce peptide stability