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In the central nervous system, pramlintide acts on the area postrema and hypothalamic satiety centers to promote feelings of fullness and reduce food intake through episodic satiety signaling, contributing to body weight reduction over chronic use

Data availability The Helsinki Biobank can provide access for research projects within the scope regulated by the Finnish Biobank Act, which is research utilizing the biobank samples or data for the purposes of promoting health, understanding the mechanisms of disease or developing products and treatment practices used in health and medical care

The liver fat substudy data deserves its own discussion because metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) is one of the largest unmet needs in metabolic medicine, and there are few approved pharmacological interventions

~ AlphaMD Your ability to sustain physical effort is one of the most powerful predictors of how long you will live - and most men have no idea where they stand

If you have type 1 diabetes, you have very few functional beta cells left