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In a 68-week randomized, placebo-controlled trial conducted by Bliddal et al
However, the endogenous secretion of GLP-1 in mice is insufficient to significantly increase the number of glutamatergic neurons in this region, potentially exacerbating anxiety-like behaviors
Mechanistic studies reveal multi-target effects, including: 1) Metabolic regulation, 2) Anti-inflammatory action, and 3) Cartilage preservation through autophagy activation and apoptosis inhibition
As shown in Supple
