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It also slows the emptying of the stomach and influences the release of insulin and glucagon from the pancreas

Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway

These combined effects help improve glycaemic control and often result in weight loss as a secondary benefit

What We Still Need Prospective, randomized trials in breast cancer survivors Mechanistic research to understand why some lab results show opposite effects More diversity in study populations by race, age, and socioeconomic status Long-term follow-up to track recurrence and survival outcomes The Bottom Line GLP-1 receptor agonists are transforming obesity care

Semaglutide Examined in Older Adults Older adults with obesity are often considered medically vulnerable because they frequently have multiple health conditions and greater frailty, which can increase the risk of adverse events (AEs)