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doi: 10.1038/nri2921 94 Plsson-McDermottE

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Our bodies have natural GLP-1 receptors in the gut and in the brain that acts as the reminder in our brains that tells us to stop eating when our gut signals weve had enough and that were full

25 , 26 Enteroendocrine L-cells of the small and large intestine produce both GLP-1 and GLP-2 in response to luminal glucose, with both hormones acting through G protein-coupled receptors distributed across multiple organ systems (Figure 1)

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