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Description
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Summary: Retatrutide is an unlicensed investigational drug in the UK, administered as a once-weekly subcutaneous injection only within approved clinical trials under medical supervision
Many patients tolerate the drug with minor discomfort, while a smaller group sees persistent or worsening reflux that needs careful tracking and discussion with their clinician
Novo Nordisk filed its New Drug Application with the FDA on 18 December 2025, based on data from the REDEFINE 1 trial
