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Finally, there were differences in trial designs, patient characteristics, background therapy, and endpoint definitions

In a separate meta-analysis, 21.7% of overweight/obese children were diagnosed with depression and 39.8% with anxiety, but only 18.0% of non-overweight/non-obese children had depression and 14.0% had anxiety, further stressing the importance of prioritizing effective treatment strategies4

Infusion of GLP-1 during a classical hyperglycemic clamp in non-diabetic individuals results in a marked reduction of insulin secretion in carriers of the TCF7L2 risk allele of SNP rs7903146