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GLP-1 drugs carry a warning regarding the risk of thyroid cancer

After 108 weeks, changes in UACR from baseline with lixisenatide were 1.69% [(95% CI: 11.69 to 8.30), p=0.7398] in patients with normoalbuminuria, 21.10% [(95% CI: 42.25 to 0.04), p=0.0502] in patients with microalbuminuria, and 39.18% [(95% CI: 6853 to 984), p=0.0070] in patients with macroalbuminuria

Orforglipron's demonstration that a small molecule could achieve clinically relevant GLP-1 receptor activation upended this assumption and opened a new chapter in incretin-based therapeutics

Overall, these results may be used for preliminary MNT guidance for this population, and the researchers call for future large-scale studies to confirm these findings and develop more specific nutritional protocols that account for the unique needs of GLP-1RA users

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