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However, slowing the digestive process can disrupt the normal movement of stool through your intestines, leading to either constipation or loose stools depending on your individual gut biology

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doi: 10.1038/nm.3761 79 CoskunTUrvaSRoellWCQuHLoghinCMoyersJSet al

Activation of GLP-1R in the hypothalamic paraventricular nucleus (PVN) triggers an appetite-suppressing response through neural pathways involving corticotropin-releasing hormone (CRH) excitatory neurons (103, 104)

Clinical studies tracking semaglutide's pharmacokinetics show a half-life of approximately seven days, meaning roughly 50 percent of the drug remains in your body after one week