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Description
A broad spectrum of secondary measures was additionally evaluated in this double-blind exenatide PD clinical trial, 47 and although none demonstrated statistical significance following correction for multiple comparisons, the majority were in the direction favoring an exenatide advantage

Abstract Background and Aims: Incretin-based therapies, including glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, are essential treatments in diabetes management due to their efficacy in glycemic control and the additional benefits of GLP-1 RAs, which include cardiovascular and renal protection

This helps keep your blood sugar from spiking and makes you feel full, so GLP-1 agonists can help you eat less

Additionally, the combined insulin and GLP-1 mechanism of action may not have the same broad appeal in a market dominated by stand-alone GLP-1 drugs

This study further confirmed the validity of this effect in non-human primates, which shows that these dual agonists have high potential of success in humans [86]
