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Second generation GLP-1 receptor agonists that were developed have more similarity with human GLP-1 and are linked to larger carrier molecules to limit renal elimination

Drug repositioning Drug repositioning is an alternative approach to identify new fields of application for existing drugs, currently approved for a different clinical condition

Oral semaglutide (Rybelsus) represents the only currently available oral GLP-1 medication

Most GLP-1 medications correlated with a lower likelihood of anxiety and depression diagnoses

Additionally, a sex-specific impact of MDD on glycemic responses in T2DM has been reported, where females are less likely to achieve normal glycemic levels [130]