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Vehicle-dosed chow-fed mice ( n = 5) served as additional controls

Balanced cohorts (n=169,630 each) were created using 1:1 propensity score matching

Stress Creates a Circadian Appetite Mismatch. Stress disrupts the natural timing of: cortisol GLP-1 SCFAs the conversion of serotonin to melatonin hunger/satiety hormones This results in: low morning appetite late-night cravings afternoon energy dips dysregulated eating patterns Your appetite becomes mis-timed because your microbiome is mis-timed

This landmark study evaluated the efficacy of semaglutide (Wegovy) and found it delivered significantly greater weight reduction than liraglutide (Saxenda) 15% mean weight loss over 68 weeks

What to expect on WeightCare semaglutide week by week Starting a semaglutide program through WeightCare (or any provider) follows a predictable pattern