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Clin J Am Soc Nephrol 12:700710 Zelniker TA, Wiviott SD, Raz I, Im K, Goodrich EL, Furtado RHM et al (2019) Comparison of the effects of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors for prevention of major adverse cardiovascular and renal outcomes in type 2 diabetes mellitus: systematic review and meta-analysis of cardio
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The caveat: clinical doses in those trials were generally 10 grams or more per day

Understanding these factors will be important for optimizing patient selection and dosing strategies
Costco's bold move makes them significantly more accessible for a select group, but the ultimate test will be whether it acts as a catalyst for wider, systemic change in how America funds these critical treatments for chronic conditions
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