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Yet physicians are finding promising uses across specialties - cardiologists prescribe them for cardiovascular disease (88 percent), gastroenterologists for nonalcoholic fatty liver disease (72 percent), and addiction medicine specialists for chemical dependency (59 percent)

However, one report of an experiment in obese humans suggested that GLP-1 (9-36amide) is a weak insulin secretagogue [198], and administration of GLP-1 (9-36amide) improves glucose handling without affecting insulin secretion in anesthetized pigs and in humans [199,200]

Clinical trials investigating the impact of DPP4 inhibition on reducing HbA1c levels in T1DM patients have yielded inconsistent results

doi: 10.1016/j.tem.2018.08.005 7 MooreAM

Previous medications like Semaglutide (Wegovy/Ozempic) target only GLP-1, while Tirzepatide (Mounjaro/Zepbound) targets GLP-1 and GIP