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Front Neurosci 9:111 Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue

Studies have shown that GLP-1R agonists not only promote insulin secretion and exert glucose-lowering effects but also effectively delay gastric emptying, reduce intestinal motility, activate neural pathways in the hypothalamus and appetite regulation areas, resulting in decreased appetite and reduced food intake, thus treating obesity

Catheterization Surgery Rats were handled daily and allowed one week to acclimate to their home cages upon arrival

Rushing the injection can cause pain, bruising, and uneven distribution of the medication

Lane W, Weinrib S, Rappaport J, Hale C