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Speaking on "The Howard Stern Show" in January 2025, Schumer, who's said a lot about her weight loss journey, said she took Ozempic around 2022 but had to stop because it resulted in severe nausea

The Danish firm wanted to refine the approach, and its research finally bore fruit

However, newer drugs like tirzepatide (Mounjaro or Zepbound) appear to have similar rates of gastrointestinal side effects compared to semaglutide

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