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Combining optimal appetite suppression with direct muscle protection could produce body composition outcomes superior to any single agent

But for a recurring monthly cost, that effect is likely modest

Retatrutide acts as a triple agonist on GLP-1, GIP, and glucagon receptors

Active gallbladder inflammation or bile duct obstruction may contraindicate semaglutide, while a history of treated gallstones may be manageable with careful monitoring

Branded partnerships, alternative weight-loss therapies, and expansion in core categories can offset some pressure, but investors will demand clearer evidence of durable unit economics without regulatory gray zones driving acquisition