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( 10.1111/dom.14174) [DOI] [PMC free article] [PubMed] [Google Scholar] Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, et al

Gut-derived hormones induce neurochemical changes in VANs by regulating a phenotypic switch. VANs exist in states that either promote orexigenic or anorexigenic phenotypes (79, 80)

Avoiding Bruising or Irritation Rotate sites : Regularly change your injection location to prevent irritation and ensure even absorption

The authors suggest this provides evidence that intestinally derived GLP-1 can compensate for the lack of -cell GLP-1

These disrupt the normal protective flora and can actually increase infection risk