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Before making dosing adjustments, discuss your specific risk profile and response history with your healthcare provider

Several trials, such as the United Kingdom Prospective Diabetes Study (UKPDS) and Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE), have demonstrated that appropriate control of blood glucose is beneficial for the reduction of long-term cardiovascular complications [4, 5]

Your body can only absorb a certain amount of water per hour, and excess is simply excreted

doi: 10.1038/npp.2014.175

Imaging and biomarker assessments (such as for inflammation or cartilage changes) are typically missing, leaving the underlying mechanisms uncertain