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When someone applies for life insurance after losing weight on GLP-1 medications, underwriters see what looks like a healthy person with: Normal BMI Improved blood pressure Better cholesterol levels Lower HbA1c levels But here's the catch: Research from the landmark STEP 1 trial extension shows that participants regain approximately two-thirds of their prior weight loss within one year of stopping semaglutide (Wilding et al., 2022)

4 Although these findings are promising, randomized clinical trials are needed to clarify the potential efficacy of GLP-1 RAs for AUD and SUD treatment

Tobacco Use Disorder Outcomes Wang, Volkow, and colleagues also conducted a study of 222,942 individuals with tobacco use disorder and type 2 diabetes, with findings showing individuals prescribed semaglutide showed a 32% lower risk of tobacco-related healthcare visits and were less likely to need smoking cessation medications or counseling during the 12-month follow-up period, with the most notable effects appearing within the first 30 days (Wang et al., 2024c)

Semaglutide (GLP-1) targets appetite control and metabolic benefits, while Tirzepatide offers enhanced results through its dual GLP-1 + GIP action

For renal safety, Rybelsus can be used in patients with an eGFR greater than 30 mL/min, while metformin is contraindicated when eGFR drops below 30 and requires dose reduction between 30-45 mL/min